Primary Diffuse Leptomeningeal Gliomatosis Mimicking Tuberculous Meningitis

Kosker M., Sener D., Kilic Ö., Hasiloglu Z. I., Islak C., KAFADAR A. M., ...More

JOURNAL OF CHILD NEUROLOGY, vol.29, no.12, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 12
  • Publication Date: 2014
  • Doi Number: 10.1177/0883073813509121
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: glioma, tuberculous meningitis, children, leptomeningeal gliomatosis, OF-THE-LITERATURE, SPINAL-CORD
  • Eskisehir Osmangazi University Affiliated: No


Primary diffuse leptomeningeal gliomatosis is a disease with an aggressive course that can result in death. To date, 82 cases have been reported. Here, the case of a 3-year-old male patient presenting with strabismus, headache, and restlessness is reported. Physical examination revealed paralysis of the left abducens nerve, neck stiffness, and bilateral papilledema. Tuberculous meningitis was tentatively diagnosed, and antituberculosis treatment was initiated when cranial imaging revealed contrast enhancement around the basal cistern. Craniocervical magnetic resonance imaging (MRI) was performed when there was no response to treatment, and it revealed diffuse leptomeningeal contrast enhancement around the basilar cistern, in the supratentorial and infratentorial compartments, and in the spinal region. Primary diffuse leptomeningeal gliomatosis was diagnosed by a meningeal biopsy.