The investigation of the prenatal and postnatal alcohol exposure-induced neurodegeneration in rat brain: protection by betaine and/or omega-3

Ol K. K., KANBAK G., Ilhan A. O., BURUKOĞLU DÖNMEZ D., YÜCEL F.

CHILDS NERVOUS SYSTEM, cilt.32, sa.3, ss.467-474, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00381-015-2990-1
  • Dergi Adı: CHILDS NERVOUS SYSTEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.467-474
  • Anahtar Kelimeler: Betaine, Caspase-3, Cytochrome c, Fetal alcohol syndrome (FAS), Omega-3, ETHANOL, ACID, ACTIVATION, CALPAIN, OMEGA-3-FATTY-ACIDS, SUPPLEMENTATION, APOPTOSIS, PROTEIN, INJURY, DAMAGE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

We aim to study the effect of neurodegeneration on the brain of rat pups caused by prenatal and postnatal ethanol exposure with modified liquid diet to elucidate protective effects of betaine and omega-3 supplementation. When ethanol is consumed during prenatal and postnatal periods, it may result in fetal alcohol syndrome (FAS) in the offspring.