The investigation of the prenatal and postnatal alcohol exposure-induced neurodegeneration in rat brain: protection by betaine and/or omega-3


Ol K. K. , KANBAK G., Ilhan A. O. , BURUKOĞLU DÖNMEZ D., YÜCEL F.

CHILDS NERVOUS SYSTEM, vol.32, no.3, pp.467-474, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.1007/s00381-015-2990-1
  • Journal Name: CHILDS NERVOUS SYSTEM
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.467-474
  • Keywords: Betaine, Caspase-3, Cytochrome c, Fetal alcohol syndrome (FAS), Omega-3, ETHANOL, ACID, ACTIVATION, CALPAIN, OMEGA-3-FATTY-ACIDS, SUPPLEMENTATION, APOPTOSIS, PROTEIN, INJURY, DAMAGE

Abstract

We aim to study the effect of neurodegeneration on the brain of rat pups caused by prenatal and postnatal ethanol exposure with modified liquid diet to elucidate protective effects of betaine and omega-3 supplementation. When ethanol is consumed during prenatal and postnatal periods, it may result in fetal alcohol syndrome (FAS) in the offspring.