Colchicine intolerance in FMF patients and primary obstacles for optimal dosing


Satis H., Armagan B., Bodakci E., Atas N., Sari A., Yasar Bilge N. Ş. , ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.50, no.5, pp.1337-1343, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-2001-261
  • Title of Journal : TURKISH JOURNAL OF MEDICAL SCIENCES
  • Page Numbers: pp.1337-1343
  • Keywords: Colchicine, side effect, intolerance, toxicity, dose, familial Mediterranean fever, RESISTANCE, MYOPATHY, THERAPY

Abstract

Background/aim: Colchicine is the mainstay of treatment in FMF. However, in daily practice it is not easy to maintain effective colchicine doses in a substantial number of patients due to its side effects. In this study, we aimed to investigate prevalence and risk factors for colchicine side effects that limit optimal drug dosing and cause permanent discontinuation.