Prediction of Preterm Delivery Using Serum Ischemia Modified Albumin, Biglycan, and Decorin Levels in Women with Threatened Preterm Labor
RBGO Gynecology and Obstetrics, vol.45, no.12, pp.754-763, 2023 (Scopus)
- Publication Type: Article / Article
- Volume: 45 Issue: 12
- Publication Date: 2023
- Doi Number: 10.1055/s-0043-1772593
- Journal Name: RBGO Gynecology and Obstetrics
- Journal Indexes: Scopus, MEDLINE
- Page Numbers: pp.754-763
- Eskisehir Osmangazi University Affiliated: Yes
Abstract
Objective The serum ischemia modified albumin (IMA), biglycan, and decorin levels of
pregnant women who were hospitalized for threatened preterm labor were measured.
Methods Fifty-one consecutive pregnant women with a single pregnancy between
the 24th and 36th weeks with a diagnosis of threatened preterm labor were included in
the present prospective cohort study.
Results As a result of multivariate logistic regression analysis for predicting preterm
delivery within 24 hours, 48 hours, 7 days, 14 days, 35 gestational weeks, and 37
gestational weeks after admission, area under the curve (AUC) (95% confidence
interval [CI[) values were 0.95 (0.89–1.00), 0.93 (0.86–0.99), 0.91 (0.83–0.98),
0.92 (0.85–0.99), 0.82 (0.69–0.96), and 0.89 (0.80–0.98), respectively. In the present
study, IMA and biglycan levels were found to be higher and decorin levels lower in
women admitted to the hospital with threatened preterm labor and who gave preterm
birth within 48 hours compared with those who gave birth after 48 hours.
Conclusion In pregnant women admitted to the hospital with threatened preterm
labor, the prediction preterm delivery of the combined model created by adding IMA,
decorin, and biglycan in addition to the TVS CL measurement was higher than
the TVS CL measurement alone.