Which definition should be used to determine colchicine resistance among patients with familial Mediterranean fever?

Demir S.

Clinical and experimental rheumatology, vol.36, no.6, pp.97-102, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2018
  • Journal Name: Clinical and experimental rheumatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.97-102
  • Keywords: familial Mediterranean fever, colchicine resistance, colchicine unresponsiveness, RECOMMENDATIONS, ASSOCIATION, MANAGEMENT, DIAGNOSIS, ANAKINRA, CRITERIA, CHILDREN, SCORE, FMF
  • Eskisehir Osmangazi University Affiliated: No


Objective. Colchicine is the main therapy for familial Mediterranean fever (FMF); however, 5-10% of patients are colchicine-resistant. There is no standard and validated definition for colchicine resistance. We aimed to compare the existing definitions for colchicine resistance in both adult and paediatric FMF patients to find out the best definition to determine colchicine-resistant patients.