Synergistic Activities of Three Triazoles with Caspofungin against Candida glabrata Isolates Determined by Time-Kill, Etest, and Disk Diffusion Methods

Kiraz, Nuri; DAĞ, İLKNUR; YAMAÇ, MUSTAFA; Kiremitci, Abdurrahman; KAŞİFOĞLU, NİLGÜN; ÖZ, YASEMİN

doi:10.1128/aac.01527-09

Synergistic Activities of Three Triazoles with Caspofungin against Candida glabrata Isolates Determined by Time-Kill, Etest, and Disk Diffusion Methods

Kiraz N., DAĞ İ., YAMAÇ M., Kiremitci A., KAŞİFOĞLU N., ÖZ Y.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, cilt.54, sa.5, ss.2244-2247, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 54 Sayı: 5
Basım Tarihi: 2010
Doi Numarası: 10.1128/aac.01527-09
Dergi Adı: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.2244-2247
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Combinations of voriconazole, fluconazole, and itraconazole with caspofungin were evaluated against 50 Candida glabrata isolates by the time-kill, disk diffusion, and Etest methods. The majority of antifungal combinations were indifferent. By the time-kill method, synergistic activity was detected with eight (16%) of the caspofungin-voriconazole and seven (14%) of the caspofungin-fluconazole combinations, but synergy was not seen with the caspofungin-itraconazole combination. Further comparisons of the Etest and disk diffusion synergy techniques with the time-kill method are warranted.