INACTIVATION OF PSEUDOMONAS AERUGINOSA PLANKTONIC BACTERIA BY SURFACE DIELECTRIC BARRIER DISCHARGE PLASMA

Durmuş Ç., Akan T.

TURKISH PHYSICAL SOCIETY 39TH INTERNATIONAL PHYSICS CONGRESS, Muğla, Türkiye, 31 Ağustos - 04 Eylül 2023, cilt.1, sa.1, ss.104

  • Yayın Türü: Bildiri / Özet Bildiri
  • Cilt numarası: 1
  • Basıldığı Şehir: Muğla
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.104
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Pseudomonas aeruginosa is a gram-negative bacterium and is widely found in the environment. This bacterium can live in various environments such as soil, water, and plants. However, it is a potential pathogen that can cause infections in people with weak immune systems or in hospital settings. The bacterium Pseudomonas aeruginosa is naturally resistant to many common antimicrobial drugs, including antistaphylococcal penicillins, amoxicillin-clavulanate, ampicillin-sulbactam, first and second-generation cephalosporins, some third-generation cephalosporins such as cefotaxime, ceftriaxone, and trimethoprim-sulfamethoxazole. This bacterium can also develop multiple antibiotic resistance by different mechanisms. It can complicate the treatment of infections due to its ability to develop resistance to the antimicrobial agents used rapidly. The bacterium Pseudomonas aeruginosa can cause a range of health problems in humans. This bacterium can cause serious infections, usually hospital-acquired infections, especially in people with weak immune systems and in patients after surgery. It can also cause lung infections, urinary tract infections, skin infections, and infected burns. Pseudomonas aeruginosa is also known for its ability to be resistant to antibiotics, which can make treatment difficult. Cold plasmas are used in many different applications in the medical field, especially in sterilization, as they produce charged atoms and/or molecules such as electrons and ions, high-energy excited atoms and/or molecules, radical atoms and/or molecules such as reactive oxygen and nitrogen species such as OH. and NO., and species and energies with high antibiofilm effect such as ozone and ultraviolet. Surface Dielectric Barrier Discharge (SDBD) is a special configuration of Dielectric Barrier Discharge (DBD) in which the dielectric material is usually placed on a flat or planar surface. In this study, a novel SDBD reactor, which can be used for samples/devices of different sizes and properties, was fabricated for antimicrobial purposes. Gram-positive Pseudomonas aeruginosa planktonic bacteria were placed in the reactor and inactivated by exposure to non-thermal plasma generated by the SDBD system for 10 minutes.