Emekli E., Demirel B. C., Emekli E.
INTERNATIONAL JOURNAL OF EATING DISORDERS, cilt.2025, ss.1-11, 2026 (SCI-Expanded, SSCI, Scopus)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
2025
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Basım Tarihi:
2026
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Doi Numarası:
10.1002/eat.70206
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Dergi Adı:
INTERNATIONAL JOURNAL OF EATING DISORDERS
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Derginin Tarandığı İndeksler:
Academic Search Ultimate (EBSCO), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Scopus, Psychology & Behavioral Sciences Collection (EBSCO), Sociology Source Ultimate (EBSCO), Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), BIOSIS, CINAHL, EMBASE, MEDLINE, Psycinfo, Social Sciences Abstracts
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Sayfa Sayıları:
ss.1-11
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Eskişehir Osmangazi Üniversitesi Adresli:
Evet
Özet
ABSTRACT
Objective
The hypothalamus plays a central role in energy homeostasis and neuroendocrine regulation, processes altered in anorexia nervosa (
AN
), yet hypothalamic morphology remains insufficiently characterized. We examined whole and subregional hypothalamic volumes in adult women with
AN
and healthy controls.
Method
This secondary analysis included 47 women with
AN
and 51 healthy controls.
T1
‐weighted
MRI
data were processed with
FastSurfer
and
FreeSurfer
. Primary comparisons adjusted for age and estimated total intracranial volume. Sensitivity analyses additionally adjusted for segmented brain volume excluding ventricular volume, restricted
AN
participants to
BMI
< 18.5 kg/m
2
, and examined
BMI
effects. Eating Disorder Examination Questionnaire associations were tested. Longitudinal weight, treatment, and endocrine data were unavailable.
Results
Whole‐hypothalamus volume was lower in
AN
(
p
= 0.006). The multivariate subregional effect was borderline (
p
= 0.049), with five subunits showing lower volumes after
FDR
correction. After global brain‐volume adjustment, the whole‐hypothalamus effect remained significant (
p
= 0.006), whereas the subregional effect was attenuated (
p
= 0.056). Among underweight participants with
AN
, whole‐hypothalamus (
p
< 0.001) and multivariate subregional differences (
p
= 0.002) remained significant after global brain‐volume adjustment, with the same five subunits surviving
FDR
correction. The group effect was not significant after
BMI
adjustment, and the initial group‐by‐
BMI
interaction was not robust to sensitivity analyses. Eating‐disorder symptom scores were not independently associated with hypothalamic volume.
Discussion
Lower hypothalamic volume in
AN
was not explained by global brain‐volume variation, although evidence for a specific subregional pattern in the full sample was less robust. Findings were strongest among underweight participants and support a close association between nutritional status and hypothalamic morphology.