It is crucial to make the most efficacious usage of solar radiation, one of the renewable energy sources increasing every day. In order to make practical usage of solar radiation, it is necessary to correctly adjust the solar panel tilt angle that collects solar radiation. Solar panel tilt angles were optimized using isotropic and anisotropic models for the first time in Eskisehir, Turkey. This study applied a mathematical model to identify the ideal tilt angles for solar panels. A combination of selected anisotropic and isotropic models was used in the calculations. The Turkish State Meteorological Service's archived data were used. The optimal tilt angles for monthly, seasonal, and annual solar panels were established. It has been discovered that the annual optimum solar panel tilt angle should be set to 33 degrees in the isotropic model, whereas in the anisotropic model, to 35 degrees. It was found that the anisotropic model approach is more advantageous than the isotropic approach in collecting solar radiation at a fixed optimum tilt angle. These findings may serve as examples for locations at different coordinates at the same latitude.