Assessment of diaphragmatic function by ultrasonography in patients with systemic sclerosis and its relation to clinical parameters A case-control study

YAKUT ÖZDEMİR H., Yalcinkaya G., ÖZYÜREK S., ÖZALEVLİ S., SALIK ŞENGÜL Y., BİRLİK A. M.

WIENER KLINISCHE WOCHENSCHRIFT, 2023 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2023
  • Doi Number: 10.1007/s00508-023-02163-x
  • Journal Name: WIENER KLINISCHE WOCHENSCHRIFT
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, MLA - Modern Language Association Database, Veterinary Science Database
  • Keywords: Systemic sclerosis, Diaphragm, Thickening fraction, Pulmonary function test, Maximum respiratory pressures, LUNG-DISEASE, STANDARDIZATION, MOBILITY, PHYSIOLOGY, ULTRASOUND, THICKNESS, FEATURES, DYSPNEA, COPD
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

BackgroundDiaphragmatic function can be affected in many diseases and disorders. Although systemic sclerosis (SSc) is a serious connective tissue disease that affects not only the skin but also the pulmonary and musculoskeletal systems, there is insufficient information about diaphragm function.AimsTo compare the diaphragmatic parameters by ultrasonography (USG) in patients with SSc and healthy individuals and examine the relationship between these parameters and clinical features in patients with SSc.MethodsThis study included 13 patients with SSc and 15 healthy individuals. Muscle thickness (in deep inspiration T-ins and at the end of calm expiration T-exp), changes in thickness ( increment T), and thickening fraction at deep breathing were evaluated by USG. Skin thickness, pulmonary function tests, respiratory muscle strength, and the perception of dyspnea were measured as clinical features.ResultsThe results of T-exp,T- T-ins,T- and increment T were similar in both groups (p > 0.05), albeit patients in the SSc group had less thickening fraction compared to the control group (79.9 +/- 36.7 cm and 103.8 +/- 20.6 cm, respectively, p < 0.05). The T-ins, increment T, and thickening fraction of the diaphragm were associated with skin thickness, pulmonary function test parameters, and respiratory muscle strength (p < 0.05). Besides, there was significant correlation between muscle thickening fraction and perception of dyspnea (p < 0.05).ConclusionThese results confirm that diaphragm thickness and contractility can be affected in patients with SSc. Therefore, ultrasonographic evaluation of the diaphragm can play a complementary role to pulmonary function test and respiratory muscle strength measurement in the diagnosis and follow-up of patients with SSc.