Synthesis and anti-Candida activity of novel 2-hydrazino-1,3-thiazole derivatives

Maillard L. T., Bertout S., Quinonero O., AKALIN ÇİFTÇİ G., Turan-Zitouni G., Fulcrand P., ...More

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol.23, no.6, pp.1803-1807, 2013 (SCI-Expanded) identifier identifier identifier


Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species. (C) 2013 Elsevier Ltd. All rights reserved.