Biotransformation of racemic diisophorone by Cephalosporium aphidicola and Neurospora crassa

KIRAN İ., AKAR T., Gorgulu A., Kazaz C.

BIOTECHNOLOGY LETTERS, vol.27, no.14, pp.1007-1010, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 14
  • Publication Date: 2005
  • Doi Number: 10.1007/s10529-005-7868-y
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1007-1010
  • Eskisehir Osmangazi University Affiliated: Yes


Racemic diisophorone (500 mg) was converted by Cephalosporium aphidicola and Neurospora crassa over 10 days at 25 degrees C to 8 beta-hydroxydiisophorone in yields of 10% (52 mg) and 20% (103 mg), respectively. The structure was established by IR, specific rotation, mass spectral, 1D and 2D-NMR studies.