Samter Syndrome
Airway Diseases: Volume 1-3, Springer International Publishing Ag, ss.2243-2253, 2023
- Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
- Basım Tarihi: 2023
- Doi Numarası: 10.1007/978-3-031-22483-6_116-1
- Yayınevi: Springer International Publishing Ag
- Sayfa Sayıları: ss.2243-2253
- Eskişehir Osmangazi Üniversitesi Adresli: Evet
Özet
Samter syndrome (also known as aspirin-exacerbated respiratory disease (AERD) or NSAID-exacerbated respiratory disease (NERD)) consists of the co-occurrence in an individual of asthma, chronic rhinosinusitis with nasal polyp formation (CRSwNP), and sensitivity to aspirin or other NSAIDs. Aspirin is also known as acetylsalicylic acid (ASA). In common with several other NSAIDs, aspirin inhibits the cyclo-oxygenase 1 (COX-1) enzyme. Aspirin sensitivity affects both the upper and lower portions of the respiratory tract. Over the past few years, a rapid development in the knowledge of the pathogenesis and clinical characteristics of ST has happened. The management of AERD is challenging as no single modality has proven to have high rates of symptom control. Consequently, disease management typically involves a multimodality approach across both medical and surgical disciplines. There is also a need for continued research efforts in pathophysiology, treatment, and possible prevention.