The Role of Ionic Homeostasis in Cisplatin-Induced Neurotoxicity: A Preliminary Study


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ÇENGELLİ ÜNEL Ç. , Erol K.

EURASIAN JOURNAL OF MEDICINE, cilt.50, sa.2, ss.81-85, 2018 (ESCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/eurasianjmed.2018.17233
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Sayfa Sayıları: ss.81-85

Özet

Objective: The aim of the present study was to investigate the role of ionic homeostasis in cisplatin (cisdiamminedichloroplatinum (II), CDDP)-induced neurotoxicity. CDDP is a severely neurotoxic antineoplastic agent that causes neuronal excitotoxicity. According to some studies, calcium influx increases, whereas potassium efflux decreases neuronal death. Nimodipine and glibenclamide were used to analyze the role of ionic flows in CDDP-induced neurotoxicity in rat primary cerebellar granule cell (CGC) culture.