The Role of Ionic Homeostasis in Cisplatin-Induced Neurotoxicity: A Preliminary Study


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ÇENGELLİ ÜNEL Ç., Erol K.

EURASIAN JOURNAL OF MEDICINE, cilt.50, sa.2, ss.81-85, 2018 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5152/eurasianjmed.2018.17233
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.81-85
  • Anahtar Kelimeler: Cerebellar granule cells, glibenclamide, KATP channels, nimodipine, CEREBELLAR GRANULE CELLS, PLATINUM COMPOUNDS, CYTOSOLIC CALCIUM, CHANNEL CURRENTS, IN-VIVO, NEURONS, ACTIVATION, INHIBITION, NEUROPROTECTION, MECHANISMS
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: The aim of the present study was to investigate the role of ionic homeostasis in cisplatin (cisdiamminedichloroplatinum (II), CDDP)-induced neurotoxicity. CDDP is a severely neurotoxic antineoplastic agent that causes neuronal excitotoxicity. According to some studies, calcium influx increases, whereas potassium efflux decreases neuronal death. Nimodipine and glibenclamide were used to analyze the role of ionic flows in CDDP-induced neurotoxicity in rat primary cerebellar granule cell (CGC) culture.