EURASIAN JOURNAL OF MEDICINE, vol.50, no.2, pp.81-85, 2018 (Journal Indexed in ESCI)
Article / Article
Title of Journal :
EURASIAN JOURNAL OF MEDICINE
Cerebellar granule cells, glibenclamide, KATP channels, nimodipine, CEREBELLAR GRANULE CELLS, PLATINUM COMPOUNDS, CYTOSOLIC CALCIUM, CHANNEL CURRENTS, IN-VIVO, NEURONS, ACTIVATION, INHIBITION, NEUROPROTECTION, MECHANISMS
Objective: The aim of the present study was to investigate the role of ionic homeostasis in cisplatin (cisdiamminedichloroplatinum (II), CDDP)-induced neurotoxicity. CDDP is a severely neurotoxic antineoplastic agent that causes neuronal excitotoxicity. According to some studies, calcium influx increases, whereas potassium efflux decreases neuronal death. Nimodipine and glibenclamide were used to analyze the role of ionic flows in CDDP-induced neurotoxicity in rat primary cerebellar granule cell (CGC) culture.