The Role of Ionic Homeostasis in Cisplatin-Induced Neurotoxicity: A Preliminary Study


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ÇENGELLİ ÜNEL Ç. , Erol K.

EURASIAN JOURNAL OF MEDICINE, vol.50, no.2, pp.81-85, 2018 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.5152/eurasianjmed.2018.17233
  • Title of Journal : EURASIAN JOURNAL OF MEDICINE
  • Page Numbers: pp.81-85
  • Keywords: Cerebellar granule cells, glibenclamide, KATP channels, nimodipine, CEREBELLAR GRANULE CELLS, PLATINUM COMPOUNDS, CYTOSOLIC CALCIUM, CHANNEL CURRENTS, IN-VIVO, NEURONS, ACTIVATION, INHIBITION, NEUROPROTECTION, MECHANISMS

Abstract

Objective: The aim of the present study was to investigate the role of ionic homeostasis in cisplatin (cisdiamminedichloroplatinum (II), CDDP)-induced neurotoxicity. CDDP is a severely neurotoxic antineoplastic agent that causes neuronal excitotoxicity. According to some studies, calcium influx increases, whereas potassium efflux decreases neuronal death. Nimodipine and glibenclamide were used to analyze the role of ionic flows in CDDP-induced neurotoxicity in rat primary cerebellar granule cell (CGC) culture.