Synthesis and biological evaluation of some new pyrimidine bearing 2,5-disubstituted 1,3,4-oxadiazole derivatives as cytotoxic agents

---

Copy For Citation

Kaya B., KAPLANCIKLI Z. A., YURTTAŞ L., AKALIN ÇİFTÇİ G.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.42, no.2, pp.131-137, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 42 Issue: 2
• Publication Date: 2017
• Doi Number: 10.1515/tjb-2016-0240
• Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.131-137
• Eskisehir Osmangazi University Affiliated: No

Abstract

Objective: As a result of adverse effects including drug-resistance, toxicity and low bioavailability, there has been a crucial need for novel anticancer agents. In this present study, some novel 2,5-disubstituted 1,3,4-oxadiazole derivatives bearing pyridine moiety were synthesized and their potential cytotoxic activities were examined.