Characterization and biological applications of CaCO<sub>3</sub>@Co<sub>0.5</sub>Zn<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub> nanoparticles

Nimafar M., El-Nabulsi R. A., Anukool W., Haris S. A., Isfahani B. K., Javanifar R., ...More

APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, vol.130, no.4, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 130 Issue: 4
  • Publication Date: 2024
  • Doi Number: 10.1007/s00339-024-07367-0
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, INSPEC, Metadex
  • Eskisehir Osmangazi University Affiliated: Yes


CaCO3 coating was applied to the surface of Co0.5Zn0.5Fe2O4 (CZF) nanoparticles by chemical co-precipitation method. CaCO3-coated CZF(CC@CZF) and bare CZF nanoparticles have been characterized by spectroscopy and microscopy techniques. XRD patterns indicate the pure cubic spinel structure of CZF nanoparticles and the growth of CaCO3 layer on the nanoparticle's surface. The spherical shape and the size distribution of the nanoparticles were assessed to be similar to 30 nm before coating and similar to 60 nm after surface functionalization and confirmed by the FESEM microscopy technique. The magnetic characteristics of samples were investigated using the vibrating sample magnetometer technique, which revealed a drop in saturation magnetization from 45 to 32 emu/g. So, coated nanoparticles performed effectively as drug transporters under both normal and magnetic field circumstances. Hydrodynamic diameters of CZF nanoparticles are similar to 726 nm and decrease to similar to 370 nm due to the surface functionalization and cause reducing particle aggregation. An MTT test was used to assess the dose-dependent cellular cytotoxicity and viability of normal human skin cells (HSF 1184), which revealed that CC@CZF nanoparticles are less harmful than bare nanoparticles.