Fluorophore-assisted synthesis of silver flowers on copper-patterned flexible substrates for SERS detection of thiram residues on apples

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DİKMEN Z., DİKMEN G., Ay K. O., AYDIN R., AKYÜZ İ.

Food Chemistry, cilt.492, 2025 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 492
• Basım Tarihi: 2025
• Doi Numarası: 10.1016/j.foodchem.2025.145656
• Dergi Adı: Food Chemistry
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
• Anahtar Kelimeler: Complexation triggered crystallization, Label free fungicide detection, SERS, Thiazolo[5,4-d]thiazole, Thiram
• Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

A rapid and non-destructive Surface-Enhanced Raman Spectroscopy (SERS) approach using silver flowers (AgFws) as a substrate was successfully developed for the detection of trace amounts of thiram, a dithiocarbamate fungicide. In this study, we report the facile preparation of AgFws on a copper-coated polyethylene terephthalate (PET) substrate utilizing a “complexation-triggered crystallization” phenomenon. The 2,5-di(pyridin-4-yl)thiazolo[5,4-d]thiazole (Py2TTz) dye serves as both a reducing agent and a nucleation site for the crystallization of silver ions, forming AgFws on the copper layer, thereby yielding a flexible SERS substrate. The copper coating enhances the formation of AgFws due to the excellent adsorption properties of the Py2TTz dye. The high surface area-to-volume ratio of the AgFws enables sensitive detection of food contaminants. The developed SERS substrate successfully identified trace amounts of thiram residues on apple peel with a detection limit of 1 pg/cm2 and in solutions with a concentration as low as 10−14 M.