EVALUATION OF THE EFFECT OF LIPID EMULSION THERAPY ON THE RAT MODEL IN ORGANOPHOSPHATE INTOXICATION AND TISSUE PATHOLOGIES


Celikel E., Arslan E. D., Yilmaz F., Unal M. T., Turhan T., Turhan N., ...More

ACTA MEDICA MEDITERRANEA, vol.30, no.6, pp.1279-1283, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 6
  • Publication Date: 2014
  • Journal Name: ACTA MEDICA MEDITERRANEA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1279-1283
  • Keywords: Malathion, lipid emulsion therapy, rat
  • Eskisehir Osmangazi University Affiliated: No

Abstract

Introduction and objective: Organophosphates are frequently used for agricultural spraying in an uncontrolled manner in our country. Humans are usually inadvertently exposed to these chemicals via respiratory, transdermal, or tranconjunctival routes whereas they may also be used for suicidal purposes: Having a high morbidity and mortality, this intoxication causes a high emergency department admission rate (1). Previous studies on lipid therapy in cardiac arrest associated with intoxication of lipophilic agents such as antidepressants, anticonvulsants, antihypertensives, and local anesthetics have reported a 55% increase in survival with these therapies (2). We also studied lipid emulsion therapy (LET) in poisoning with organophosphates that are lipophilic.