EVALUATION OF THE EFFECT OF LIPID EMULSION THERAPY ON THE RAT MODEL IN ORGANOPHOSPHATE INTOXICATION AND TISSUE PATHOLOGIES


Celikel E., Arslan E. D., Yilmaz F., Unal M. T., Turhan T., Turhan N., ...Daha Fazla

ACTA MEDICA MEDITERRANEA, cilt.30, sa.6, ss.1279-1283, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 6
  • Basım Tarihi: 2014
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1279-1283
  • Anahtar Kelimeler: Malathion, lipid emulsion therapy, rat
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Introduction and objective: Organophosphates are frequently used for agricultural spraying in an uncontrolled manner in our country. Humans are usually inadvertently exposed to these chemicals via respiratory, transdermal, or tranconjunctival routes whereas they may also be used for suicidal purposes: Having a high morbidity and mortality, this intoxication causes a high emergency department admission rate (1). Previous studies on lipid therapy in cardiac arrest associated with intoxication of lipophilic agents such as antidepressants, anticonvulsants, antihypertensives, and local anesthetics have reported a 55% increase in survival with these therapies (2). We also studied lipid emulsion therapy (LET) in poisoning with organophosphates that are lipophilic.