Prenatal alcohol-induced neuroapoptosis in rat brain cerebral cortex: protective effect of folic acid and betaine

Sogut I., UYSAL O., Oglakci A., YÜCEL F., Kartkaya K., KANBAK G.

CHILDS NERVOUS SYSTEM, cilt.33, sa.3, ss.407-417, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s00381-016-3309-6
  • Dergi Adı: CHILDS NERVOUS SYSTEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.407-417
  • Anahtar Kelimeler: Betaine, Calpain, Caspase-3, Cytochrome c, Folic acid, Neuroapoptosis, INDUCED APOPTOTIC NEURODEGENERATION, CYTOCHROME-C RELEASE, TO-NEURON RATIOS, CEREBELLAR CORTEX, ETHANOL, EXPOSURE, CALPAIN, MITOCHONDRIA, ACTIVATION, SUPPLEMENTATION
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Purpose Alcohol consumption in pregnancy may cause fetal alcohol syndrome (FAS) in the infant. This study aims to investigate prenatal alcohol exposure related neuroapoptosis on the cerebral cortex tissues of newborn rats and possible neuroprotective effects of betaine, folic acid, and combined therapy.