Successful treatment of hepatitis B-associated leukocytoclastic vasculitis with lamivudine treatment in a child patient

Onay Ö., Baskin E., Ozcay F., Melek E., Canan O., Bilezikci B.

RHEUMATOLOGY INTERNATIONAL, cilt.27, sa.9, ss.869-872, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 9
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00296-006-0295-0
  • Dergi Adı: RHEUMATOLOGY INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.869-872
  • Anahtar Kelimeler: hepatitis B infection, vasculitis, treatment, lamivudine, ALPHA, AUTOANTIBODIES, THERAPY
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Chronic hepatitis B infection (HBI) has many extrahepatic manifestations such as vasculitis, glomerulonephritis, arthritis, dermatitis, pulmonary disease, and skin manifestations. The mechanism of these manifestations is thought to be immune mediated. Immune-suppressive treatment may enhance viral replication and worsen hepatic disease. Lamivudine is a nucleoside analogue used in chronic HBI treatment that works by suppressing replication of the hepatitis B virus (HBV). Recently, several reports have suggested that lamivudine treats vasculitis associated with HBV infection in adults. However, there are no data in the literature for children. Herein, we report a child with leukocytoclastic vasculitis due to chronic HBI who was successfully treated with lamivudine.