Evaluation of the hemodynamic responses to the exogen vasopressin in rats with hemorrhagic and septic shock model Hemorajik ve Septik Şok Modeli Oluşturulan Siçanlarin Ekzojen Vazopressine Verdikleri Hemodinamik Yanitlarin Deǧerlendirilmesi

Atakan I., Bilir A., Ekemen S., Sirmagül B., Erol K., Tanriverdi B.

Gogus-Kalp-Damar Anestezi ve Yogun Bakim Dernegi Dergisi, cilt.11, ss.96-101, 2005 (Scopus) identifier

Özet

Vasopressin is a potent vasoconstrictor that can be used in different hypotensive conditions. The aim of our study was to determine the relation between vasopressin and nitric oxide that release in shock and the effect on hemodynamic responses in hemorrhagic and endotoxic shock. Tracheotomy and invasive cannulation were performed in 30 rats. After stabilization period for 20 minutes, blood samples were taken for nitric oxide levels. Rats were randomized to 3 groups; Group I (hemorrhagic shock), Group II (endotoxic shock), Group III (control group). Vasopressin was infused in all groups after the stabilization period. Heart rates and mean arterial blood pressures were recorded periodically. Blood samples were repeated at the 30th minutes of the shock and 30th minutes of the infusion of vasopressin. Mean arterial blood pressures were at the lowest level at 30th minute of the study and the difference between groups was statistically significant at the same time point. There was statistically signifcant decrease of heart rate in group I at 15th minutes of the infusion of vasopressin. There was a statistically significant increase in nitric oxide levels in septic shock group. We observe that, vasopressin can increase blood pressures, but this effect was not in relation with nitric oxide. Lower doses of vasopressin do not affect heart rates and this may be an advantage to the routine catecholamine therapy.