Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents

ALTINTOP M. D., SEVER B., ÖZDEMİR A., ILGIN S., ATLI Ö., Turan-Zitouni G., ...More

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, vol.18, no.11, pp.1606-1616, 2018 (SCI-Expanded) identifier identifier identifier


Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and their cytotoxic effects on A549 human lung adenocarcinoma, MCF-7 human breast adenocarcinoma, HepG2 human hepatocellular carcinoma and NIH/3T3 mouse embryonic fibroblast cell lines were investigated using Mil' assay.