Synthesis and Evaluation of a Series of 1,3,4-Thiadiazole Derivatives as Potential Anticancer Agents

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Atıf İçin Kopyala

ALTINTOP M. D., SEVER B., ÖZDEMİR A., ILGIN S., ATLI Ö., Turan-Zitouni G., ...Daha Fazla

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.11, ss.1606-1616, 2018 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 18 Sayı: 11
• Basım Tarihi: 2018
• Doi Numarası: 10.2174/1871520618666180509111351
• Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.1606-1616
• Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Background and Methods: In an attempt to develop potent antitumor agents, the synthesis of a series of N-(6-substituted benzothiazol-2-yl)-2-1(5-(arylamino)-1,3,4-thiadiazol-2-yl)thiolacetamides (1-14) was described and their cytotoxic effects on A549 human lung adenocarcinoma, MCF-7 human breast adenocarcinoma, HepG2 human hepatocellular carcinoma and NIH/3T3 mouse embryonic fibroblast cell lines were investigated using Mil' assay.