Association of eleven single nucleotide polymorphisms with refractive disorders from Eskisehir, Turkey

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Unlu N., Gokalp E. E., Arslan S., Çilingir O., Bilgin M., Yıldırım E., ...More

International Journal of Ophthalmology, vol.14, no.6, pp.812-817, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.18240/ijo.2021.06.05
  • Journal Name: International Journal of Ophthalmology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
  • Page Numbers: pp.812-817
  • Keywords: refractive disorders, myopia, hyperopia, genetics, single nucleotide polymorphisms, Turkey, HEPATOCYTE GROWTH-FACTOR, FACTOR GENE, HIGH MYOPIA, VITAMIN-D, HGF
  • Eskisehir Osmangazi University Affiliated: Yes


© 2021 International Journal of Ophthalmology (c/o Editorial Office). All rights reserved.AIM: To investigate relationship between refractive errors and eleven single nucleotide polymorphisms (SNPs) in HGF, GC, MFN1, GNB4, and VDR genes in Turkish population. METHODS: A group of 212 participants with myopia (n=91), hyperopia (n=45), and emmetropia (n=76) were investigated in this study. SNPs in HGF, GC, MFN1, GNB4 and VDR genes were studied by SnapShot technique. RESULTS: The patients in this study consists of 47 female/44 male (age: 23.47±4.30) patients with myopia, 20 female/25 male (age: 31.20±8.02) with hyperopia and 33 female/43 male (age: 25.22±6.60) with emmetropia. The genotype distribution of the rs7618348 polymorphism, which was the only statistically significant one between myopia and emmetropia group. The genotype distribution of the rs3819545, rs3735520, rs7041, and rs2239182 polymorphisms, which were statistically significant between hyperopia and emmetropia groups. CONCLUSION: The importance of genetic predisposition to refractive errors with respect to etiology of the disease is revealed. It is known that polymorphism studies may differ because of genetic diversity among populations so larger cohort studies are required in different populations to enlighten the etiology of the refractive errors.