7-Substituted Hexahydroquinoline Derivatives and their Calcium Channel Modulator Effects

GÜNDÜZ M. G., Celebi S., KAYGISIZ B., ŞİMŞEK R., Erol K., Safak C.

LATIN AMERICAN JOURNAL OF PHARMACY, cilt.28, sa.6, ss.922-926, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 2009
  • Dergi Adı: LATIN AMERICAN JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.922-926
  • Anahtar Kelimeler: Calcium antagonistic activity, Hexahydroquinoline, Nicardipine, Synthesis, 1,4-DIHYDROPYRIDINE, ANTAGONISTS
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, calcium antagonistic activity of sixteen hexahydroquinoline derivatives have been elucidated in rat ileum and rat thorasic aorta. In the studies on isolated rat ileum, it has been observed that all compounds showed meaningfull activity. In rat thorasic aorta studies, compound 3a has been found more active than nicardipine.