IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme

Kalkan, Rasime; Atli, Emine; Ozdemir, Muhsin; Ciftci, Evrim; Aydin, HASAN; ARTAN, SEVİLHAN; ARSLANTAŞ, ALİ

doi:10.1016/j.gene.2014.10.027

IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme

Kalkan R., Atli E. I., Ozdemir M., Ciftci E., Aydin H. E., ARTAN S., ...Daha Fazla

GENE, cilt.554, sa.1, ss.81-86, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 554 Sayı: 1
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.gene.2014.10.027
Dergi Adı: GENE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.81-86
Anahtar Kelimeler: Primary glioblastoma, IDH1 mutation, MGMT methylation, MS-HRM, CODON 132 MUTATION, PROMOTER METHYLATION, SURVIVAL, GLIOMAS
Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Purpose: To establish the frequency of IDH1 mutations and MGMT methylation in primary glioblastomas. Experimental design: We screened primary glioblastoma multiforme (GBM) in a population-based study for IDH1 mutations and MGMT methylation and correlated them with clinical data.