IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme

Kalkan, Rasime; Atli, Emine; Ozdemir, Muhsin; Ciftci, Evrim; Aydin, HASAN; ARTAN, SEVİLHAN; ARSLANTAŞ, ALİ

doi:10.1016/j.gene.2014.10.027

IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme

Kalkan R., Atli E. I., Ozdemir M., Ciftci E., Aydin H. E., ARTAN S., ...More

GENE, vol.554, no.1, pp.81-86, 2015 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 554 Issue: 1
Publication Date: 2015
Doi Number: 10.1016/j.gene.2014.10.027
Journal Name: GENE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.81-86
Keywords: Primary glioblastoma, IDH1 mutation, MGMT methylation, MS-HRM, CODON 132 MUTATION, PROMOTER METHYLATION, SURVIVAL, GLIOMAS
Eskisehir Osmangazi University Affiliated: Yes

Abstract

Purpose: To establish the frequency of IDH1 mutations and MGMT methylation in primary glioblastomas. Experimental design: We screened primary glioblastoma multiforme (GBM) in a population-based study for IDH1 mutations and MGMT methylation and correlated them with clinical data.