IDH1 mutations is prognostic marker for primary glioblastoma multiforme but MGMT hypermethylation is not prognostic for primary glioblastoma multiforme

Kalkan R., Atli E. I., Ozdemir M., Ciftci E., Aydin H. E., ARTAN S., ...More

GENE, vol.554, no.1, pp.81-86, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 554 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.gene.2014.10.027
  • Journal Name: GENE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.81-86
  • Keywords: Primary glioblastoma, IDH1 mutation, MGMT methylation, MS-HRM, CODON 132 MUTATION, PROMOTER METHYLATION, SURVIVAL, GLIOMAS
  • Eskisehir Osmangazi University Affiliated: Yes


Purpose: To establish the frequency of IDH1 mutations and MGMT methylation in primary glioblastomas. Experimental design: We screened primary glioblastoma multiforme (GBM) in a population-based study for IDH1 mutations and MGMT methylation and correlated them with clinical data.