Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery

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Toprak C., SIRMAGÜL B., YİĞİTASLAN S.

EURASIAN JOURNAL OF MEDICINE, cilt.49, sa.3, ss.188-192, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 49 Sayı: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/eurasianjmed.2017.17046
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.188-192
  • Anahtar Kelimeler: Alagebrium, calcium channel blockage, carotid artery, nitric oxide, vasodilatation, GLYCATION END-PRODUCTS, CROSS-LINK BREAKER, RECEPTOR, ALT-711, AGES
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: In our study, the effects of glycosylated protein cross-link breaker, alagebrium was investigated on isolated rat carotid artery using myography. Alagebrium showed vasodilator effect on carotid artery rings; particularly, this effect was significantly increased in endothelium-intact rings.