Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats

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Kocak C., Kocak F. E., AKCILAR R., Isiklar Ö. Ö., Kocak H., Bayat Z., ...More

LIFE SCIENCES, vol.147, pp.15-23, 2016 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 147
• Publication Date: 2016
• Doi Number: 10.1016/j.lfs.2016.01.038
• Journal Name: LIFE SCIENCES
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.15-23
• Keywords: Carnosic acid, Embelin, Heart, Isoproterenol, Myocardial infarction, Myocardial ischemia, ISCHEMIA-REPERFUSION INJURY, DECREASES CARDIOMYOCYTE APOPTOSIS, CULTURED CARDIAC MYOCYTES, OXIDATIVE STRESS, INDUCED CARDIOTOXICITY, ANTIOXIDANT RESPONSE, BINDING PROTEIN, TROPONIN-I, DAMAGE, HEART
• Eskisehir Osmangazi University Affiliated: No

Abstract

Aims: Acute myocardial infarction is a serious acute cardiac disorder and heart disease is still a major public health problem in adults. We investigated the effects of embelin (EMB) and carnosic acid (CA) in animals with isoproterenol (ISO)-induced myocardial injury.