Preventive effect of betaine on ethanol-induced membrane lipid composition and membrane ATPases

Kanbak G., Akyuz F., Inal M.

ARCHIVES OF TOXICOLOGY, vol.75, no.1, pp.59-61, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 1
  • Publication Date: 2001
  • Doi Number: 10.1007/s002040000179
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.59-61
  • Keywords: ethanol, betaine, Na+-K+ ATPase, Ca2+-Mg2+ ATPase, membrane lipids
  • Eskisehir Osmangazi University Affiliated: Yes


The aim of this study was to observe ethanol-induced membrane injury and to investigate the protective effect of betaine against chronic ethanol toxicity. Rats were divided into three groups, control group (n=8), ethanol (8 g/kg per day) group (n=8) and ethanol plus betaine (0.5% w/v) group (n = 8), Cholesterol concentrations (P<0.05) and the cholesterol; phospholipid (C/PL) molar ratio (P< 0.01) were significantly increased in the erythrocyte membranes of ethanol-treated rats compared with those of the control group. Cholesterol (P<0.05) and the C/PL ratio (P<0.01) were decreased to control group levels after betaine administration. The activities of Ca2+-Mg2+ ATPase and Na+-K+ ATPase were lower than those of the control group (both P<0.001), but the activities of these enzyme were increased in the betaine treatment group (P < 0.05), Our findings show that chronic ethanol consumption may affect membrane functions and betaine administration may be a useful agent for the treatment of chronic ethanol toxicity.