Association of Alzheimer's Disease With APOE and IL-1 alpha Gene Polymorphisms

YILDIZ S. H., Erdogan M. O., ARTAN S., SOLAK M., YAMAN M., Ozbabalik B. D., ...Daha Fazla

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, cilt.30, sa.8, ss.756-761, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/1533317512461557
  • Dergi Adı: AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.756-761
  • Anahtar Kelimeler: Alzheimer's disease, apolipoprotein E, interleukin-1 alpha, polymorphism, APOLIPOPROTEIN-E POLYMORPHISM, VASCULAR DEMENTIA, CORTICAL-NEURONS, RISK-FACTORS, ONSET, ALLELE, INTERLEUKIN-1, POPULATION, GENOTYPE, EPIDEMIOLOGY
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1 (IL-1) is found to be associated with the pathogenesis of AD. In this research, 2, 3, and 4 polymorphisms of ApoE gene and C889T polymorphism of IL-1 gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. 3/3 and 3/4 genotype frequencies were significantly higher in control and case groups, respectively. While 3 allele frequencies were significantly higher in the control group, 2 and 4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1. In conclusion, we demonstrated that there was a strong association between ApoE 4 allele and AD, while there was no relation with IL-1 C889T polymorphisms for this study.