Association of Alzheimer's Disease With APOE and IL-1 alpha Gene Polymorphisms

YILDIZ S. H., Erdogan M. O., ARTAN S., SOLAK M., YAMAN M., Ozbabalik B. D., ...More

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, vol.30, no.8, pp.756-761, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 8
  • Publication Date: 2015
  • Doi Number: 10.1177/1533317512461557
  • Journal Name: AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.756-761
  • Keywords: Alzheimer's disease, apolipoprotein E, interleukin-1 alpha, polymorphism, APOLIPOPROTEIN-E POLYMORPHISM, VASCULAR DEMENTIA, CORTICAL-NEURONS, RISK-FACTORS, ONSET, ALLELE, INTERLEUKIN-1, POPULATION, GENOTYPE, EPIDEMIOLOGY
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1 (IL-1) is found to be associated with the pathogenesis of AD. In this research, 2, 3, and 4 polymorphisms of ApoE gene and C889T polymorphism of IL-1 gene were genotyped in patients with AD and controls. Genotyping was performed by real-time polymerase chain reaction. 3/3 and 3/4 genotype frequencies were significantly higher in control and case groups, respectively. While 3 allele frequencies were significantly higher in the control group, 2 and 4 allele frequencies were significantly higher among the cases with AD. No difference was found between the groups according to C889T polymorphism of IL-1. In conclusion, we demonstrated that there was a strong association between ApoE 4 allele and AD, while there was no relation with IL-1 C889T polymorphisms for this study.