Pyridoxine might not have a preventive effect on the retinyl palmitate-induced viscerocranial anomalies

Ay H., Ulupınar E., Uenal N.

ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, vol.192, no.2, pp.75-81, 2010 (SCI-Expanded) identifier identifier identifier


Viscerocranial anomalies are induced in the presence of various teratogens. Vitamin A-induced cleft palate formation is one of the most frequently used experimental models in these studies. However, the underlying mechanisms are not yet fully understood. Several studies have shown that exogenous vitamin A disrupts the fusion of the palatal shelves by increasing the expression of epidermal growth factor receptor (EGFR). More recently, pyridoxine (vitamin B6) has been reported to have a potentially protective effect in regard to viscerocranial malformations. Therefore, in this study, we aimed to investigate whether pyridoxine has a preventive effect on retinyl palmitate-induced viscerocranial anomalies.