Prognostic Value of Osteopontin in Patients Treated with Primary Radiotherapy for Head and Neck Cancer


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ETİZ D., Ataizi F. C., Bayman E., Akcay M. Ç., AÇIKALIN M. F., ÇOLAK E., ...More

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol.14, no.9, pp.5175-5178, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 9
  • Publication Date: 2013
  • Doi Number: 10.7314/apjcp.2013.14.9.5175
  • Journal Name: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5175-5178
  • Keywords: Head and neck cancer, local control, osteopontin, radiotherapy, side effect, SQUAMOUS-CELL CARCINOMAS, PLASMA OSTEOPONTIN, TUMOR MICROENVIRONMENT, GENE-EXPRESSION, HYPOXIA, MARKERS, TISSUE, OVEREXPRESSION, INVASIVENESS, INFLAMMATION
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: The prognostic value of tumor osteopontin (OPN) in patients with squamous-cell head and neck cancer (SCHNC) was investigated. Materials and Methods: OPN expression was assessed by immunohistochemical methods in 50 patients, who were treated with primary radiotherapy (RT) for locally advanced SCHNC. The effects of OPN on clinical parameters, local-regional control after RT and metastasis-free survival, was assessed. Results: The rate of OPN expression in tumor tissue was 76%. OPN positive cases had lower Hb levels (p=0.088). Mean time to local recurrence was 53.8 months (SE 3.9) in OPN-negative cases and 39.1 months (SE 4.7) in OPN-positive cases (p=0.047). OPN increased the risk of local recurrence 5.9 times (p=0.085). It had no effect on metastasis-free (p=0.116) or overall survival (p=0.123). OPN was positive in 12 of 19 cases that developed grade 3-4 acute radiation dermatitis (p=0.096). Conclusions: OPN expression is associated with an increase in local recurrence in patients who were treated with primary RT for locally advanced SCHNC.