IL-15 Gene Polymorphism in Celiac Disease Patients and Their Siblings

Kara Y., Eren M., Arslan S., Çilingir O.

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.32, no.4, pp.349-356, 2021 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.5152/tjg.2021.19083
  • Journal Name: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.349-356
  • Keywords: Celiac disease, IL-15, gene polymorphism, RHEUMATOID-ARTHRITIS, TURKISH CHILDREN, ASSOCIATION
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Celiac disease (CD) is an immune-mediated enteropathy characterized by lifelong gluten intolerance. lnterleukin-15 (IL-15) is a proinflammatory cytokine that is considered a key component in the immune reaction triggered by gluten. Our aim of this study was to evaluate the influence of IL-15 gene polymorphisms on CD development and clinical presentation.