40th ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR PAEDIATRIC INFECTIOUS DISEASES (ESPID), ATİNA, Greece, 09 May 2022, vol.1, no.454, pp.454
Multisystem inflammatory syndrome (MIS-C) is a pediatric hyperinflammation disorder caused by SARS-CoV-2. Today it is known that MIS-C has a large burden of clinical presentation. The range of neurologic symptoms associated with COVID-19 and MIS-C in children and adolescents was broad and varied by age. We present a MISC case with neurological involvement and transient splenial lesion was detected in cranial MRI.
The child presents to the emergency department due to the addition of exanthema in the complaints of fever, vomiting and diarrhea that started 5 days before the admission. In first examination, it was observed that he was lethargic, dehydrated, conjunctivitis in the eyes, redness on the lips, and urticarial rash on the body. In laboratory, leucocyte 10600/mm3, lymphocyte 1300/mm3, eritrocyte sedimentation rate 59 mm/h, pro-BNP:6700pg/mL, procalcitonin:69ng/mL, ferritin 650 ng/nL, echocardiography was normal. Blood and urine cultere was negative. For MIS-C, IVIG and steroid treatment was given but in first hour of infusion of IVIG, patient began to talk nonsense and began to see objects that were not on the Wall. After this transient sympthom, cranial MRI was showed transient splenial lesion on root of corpus callosum. After IVIG and steroid treatment, all inflamatory findings and clinical symphtom get normal.
Transient splenial lesions (TSL) of the corpus callosum are uncommon radiologic findings that are seen in a number of clinical conditions with varied etiologies. These lesions are usually incidentally detected when imaging is done for encephalopathy/encephalitis or seizures, and the actual incidence might be more than what reports indicate. We report a MISC case presented with neurological findings and splenial lesion was detected on MRI.