From 1982 to 1995, 374 cases with peripheral lymphadenomegaly were managed in outpatients clinics of Istanbul Medical School, in the Department of Pediatric Surgery. Of the lymphadenomegalies, 67.65% were cervical, 11.23% were submandibular, 10.70% were axillar and 2.94% were supraclavicular. A course of wide spectrum antibiotics was applied to 314 cases (83.96%) before referring for biopsy. The histopathologic evaluation of the biopsy specimens were: 70 lyphadenitis (18.72%), 180 reactive lymphadenopathy (48.13%), 124 various tumors (33.15%). Of the 180 cases of reactive lymphadenopathy, 12 were biopsied again for the persistence of the symptoms and of those 7 were found to have a form of malignancy. In our report the overall malignancy rate is quite high and this result can be explained by the fact that most of the cases are referred from Pediatric Hematology and Oncology Divisions and BCG lymphadenitis are excluded from the study group.