Asymmetric dimethylarginine and L-arginine levels in neonatal sepsis and septic shock

Aydemir Ö., Ozcan B., Yucel H., BAŞ A. Y., Demirel N.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.28, pp.977-982, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28
  • Publication Date: 2015
  • Doi Number: 10.3109/14767058.2014.939950
  • Journal Name: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.977-982
  • Keywords: Asymmetric dimethylarginine, L-arginine, neonatal sepsis, newborn, septic shock, NITRIC-OXIDE SYNTHASE, ENDOTHELIUM, METABOLISM, CHILDREN, DISEASE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Objective: Nitric oxide (NO) formed by the enzyme NO synthase (NOS) from L-arginine, is an important mediator for pathogen elimination. Being a potent vasodilator NO is implicated in hypotension and decreased organ perfusion in sepsis. Asymmetric dimethylarginine (ADMA) is an endogenous NOS inhibitor. We investigated ADMA and L-arginine levels in neonatal sepsis and their relation to disease severity.