Asymmetric dimethylarginine and L-arginine levels in neonatal sepsis and septic shock


Aydemir Ö., Ozcan B., Yucel H., BAŞ A. Y. , Demirel N.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, vol.28, pp.977-982, 2015 (SCI-Expanded) identifier identifier identifier

Abstract

Objective: Nitric oxide (NO) formed by the enzyme NO synthase (NOS) from L-arginine, is an important mediator for pathogen elimination. Being a potent vasodilator NO is implicated in hypotension and decreased organ perfusion in sepsis. Asymmetric dimethylarginine (ADMA) is an endogenous NOS inhibitor. We investigated ADMA and L-arginine levels in neonatal sepsis and their relation to disease severity.