Asymmetric dimethylarginine and L-arginine levels in neonatal sepsis and septic shock

Aydemir Ö., Ozcan B., Yucel H., BAŞ A. Y., Demirel N.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.28, ss.977-982, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/14767058.2014.939950
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.977-982
  • Anahtar Kelimeler: Asymmetric dimethylarginine, L-arginine, neonatal sepsis, newborn, septic shock, NITRIC-OXIDE SYNTHASE, ENDOTHELIUM, METABOLISM, CHILDREN, DISEASE
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Objective: Nitric oxide (NO) formed by the enzyme NO synthase (NOS) from L-arginine, is an important mediator for pathogen elimination. Being a potent vasodilator NO is implicated in hypotension and decreased organ perfusion in sepsis. Asymmetric dimethylarginine (ADMA) is an endogenous NOS inhibitor. We investigated ADMA and L-arginine levels in neonatal sepsis and their relation to disease severity.