Antimicrobial and anti-quorum-sensing properties and paint film usage of novel diazaborine-based copolymers

KOÇAK G., ÇİÇEK H., CEYLAN Ö., BÜTÜN V.

JOURNAL OF APPLIED POLYMER SCIENCE, vol.136, no.1, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 136 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.1002/app.46907
  • Journal Name: JOURNAL OF APPLIED POLYMER SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: antibacterial paint, biomedical applications, copolymers, quorum-sensing inhibition, surfaces and interfaces, ENOYL-ACP REDUCTASE, ESCHERICHIA-COLI, VIBRIO-HARVEYI, ANTIBACTERIAL ACTIVITIES, BIOFILM FORMATION, BORONIC ACIDS, BACTERIA, INHIBITORS, POLYMERS, RESISTANCE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

To meet high hygiene requirements, intensive studies are being carried out on antimicrobial materials. This study reports the synthesis of 3-((1-hydroxybenzo[d][1,2,3]diazaborinin-2(1H)-yl)sulfonyl)propyl methacrylate (DAZBMA) and its polymer, which is antimicrobial [tested with Staphylococcus aureus (ATCC 25923 and MU 40) and Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, and Candida albicans ATCC 10239] on solid surfaces. Antibiofilm capability was tested against MU 40. Although DAZBMA and its polymer show a high quorum-sensing inhibition property (tested with Chromobacterium violaceum CV 026 and CV 12472 and P. aeruginosa PA01), the lesser antibacterial activity of the polymer was improved by copolymerizing DAZBMA with quaternized 2-dimethylaminoethyl methacrylate. The paint films containing the prepared copolymer are highly active against all tested bacteria and show an antibiofilm effect against hospital-acquired multiple-antibiotic-resistant MU 40. The novel copolymer can be used in water-soluble paints to reduce its biofilm production and pathogenicity, especially for paints used in hospitals. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 46907.