The effects of N-acetylcysteine on experimentally created L-asparaginase-induced liver and pancreatic damage in rats

Yurttaş G. N., Özdemir Z. C., Tanrıkut C., Kar E., Küskü Kiraz Z., Alataş Ö., ...Daha Fazla

LEUKEMIA & LYMPHOMA, cilt.63, sa.6, ss.1445-1454, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1080/10428194.2022.2030474
  • Dergi Adı: LEUKEMIA & LYMPHOMA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.1445-1454
  • Anahtar Kelimeler: L-Asparaginase, N- acetylcysteine, liver, pancreas, ACUTE LYMPHOBLASTIC-LEUKEMIA, INDUCED HEPATOTOXICITY, OCTREOTIDE, CHILDREN, EFFICACY, METHOTREXATE, EXPRESSION, GLUTAMINE, TOXICITY, STRESS
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

In this study, oxidative stress marker (malondialdehyde, MDA) and antioxidant enzymes (glutathione (GSH), catalase (CAT)) levels in the liver and pancreas tissue and the histopathological effects of N-acetylcysteine (NAC) were investigated in L-asparaginase (L-ASP) induced liver and pancreatic damage in rats. Forty male albino rats were divided into four groups. The control group was intraperitoneally injected physiological saline (0.02 mL/g); NAC group was injected NAC (200 mg/kg, five days); L-ASP group was injected single-dose L-ASP (10,000U/kg), and LASP + NAC group was injected NAC for five days following single-dose L-ASP (10,000 U/kg). The surgical operation was performed on all animals on the fifth day. There was no difference between the groups regarding tissue MDA, GSH, and CAT levels (p>.05, for all). In the group receiving NAC after L-ASP, there was a significant improvement in the liver and pancreas damage score than the L-ASP group. NAC was effective in reducing organ damage caused by L-ASP.