In vivo effects of Viscum album and probiotics against carbon tetrachloride-induced liver injury.

Erdaş M., Akyüz F., Can B., Özkoç M., Öz S., Dönmez D.

Journal of bioenergetics and biomembranes, vol.53, no.2, pp.139-148, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1007/s10863-021-09883-7
  • Journal Name: Journal of bioenergetics and biomembranes
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, INSPEC, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.139-148
  • Keywords: Carbon tetrachloride, Hepatic function, Probiotics, Serum biochemistry, Viscum album
  • Eskisehir Osmangazi University Affiliated: Yes


This study tested the possible protective and therapeutic effects of Viscum album extract and probiotics against carbon tetrachloride (CCl4)-induced acute/chronic liver injury. Male Wistar rats were assigned to seven groups: Control, acute CCl4, acute V. album + CCl4, acute V. album + Probiotics + CCl4, chronic CCl4, chronic CCl4 + V. album, and chronic CCl4 + V. album + Probiotics. Acute and chronic liver injuries were induced by 2 mg/kg CCl4 (i.p.) and 1 mg/kg CCl4 (i.p.), respectively. The extract and probiotics were administered daily to related groups. Serum enzyme activities, lipid profile, total protein, albumin, bilirubin, heme oxgenase-1 and 8-hydroxydeoxyguanosine levels were measured. Liver tissue sections stained with Hematoxylin-Eosin. Acute or chronic CCl4-exposure caused to significant changes in concentrations/activities of the measured parameters. The oral administration of extract and probiotics showed protective and therapeutic effects against CCl4-induced liver-injury. The supplementation of intestinal flora by the use of probiotics may enhance the efficacy of orally given therapeutic extracts.