Severe consumptive hypothyroidism caused by multiple infantile hepatic haemangiomas

ŞİMŞEK E., Demiral M., Gundogdu E.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.31, no.7, pp.823-827, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 7
  • Publication Date: 2018
  • Doi Number: 10.1515/jpem-2018-0055
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.823-827
  • Keywords: consumptive hypothyroidism, infantile hepatic haemangioma, type 3 iodothyronine deiodinase., TYPE-3 IODOTHYRONINE DEIODINASE
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: Infantile hepatic haemangiomas (IHHs) produce an excess of the thyroid hormone inactivating enzyme type-3 iodothyronine deiodinase (D3), leading to rapid degradation of thyroid hormones and consum-ptive hypothyroidism. The L-thyroxine replacement dose in patients with consumptive hypothyroidism is inappropriately higher than that in congenital hypothyroidism.