Akademik Veri Yönetim Sistemi
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.6, sa.1, ss.9-13, 2016 (ESCI)
Objective: The imidazopyrazine ring is a biologically active heterocyclic ring. Many hydrazide-hydrazone-possessing compounds have been reported to have interesting bioactivity, such as antibacterial, antifungal, anticonvulsant, anti-inflammatory, antituberculosis, and analgesic activities. In particular, aroyl hydrazides/hydrazone-containing hetero-rings, such as indole, pyridine, and imidazo[2,1-b]pyridine, and imidazo[1,2-a]pyrazine, have attracted special attention. We designed and synthesized N-(4-substitutedbenzylidene) imidazo[1,2-a]pyrazine-2-carbohydrazide (2a-j) derivatives using the two aforementioned pharmacophoric units based on the synthetic procedure indicated in our previous study.