THE MUTAGENIC ACTIVITIES OF SOME STEROID DERIVATIVES USING Salmonella UMU TEST

CANBEK M., KIRAN İ., CEYHAN E., YILDIZ Z., Emeksiz H.

FRESENIUS ENVIRONMENTAL BULLETIN, cilt.19, ss.1552-1557, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19
  • Basım Tarihi: 2010
  • Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1552-1557
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The mutagenic activities of four steroid hormone derivatives, namely 6 beta-hydroxyandrost-4-ene-3,17-dione (1), 6 beta-acetoxyandrost-4-ene-3,17-dione (2), 17 beta-acetoxyandrost- 4- ene-3,6-dione (3) and cholest-4-ene-3,17-dione (4), were studied with umu test using Salmonella typhimurium NM2009 and NM3009 strains. The results showed that the highest mutagenic activity was exhibited by the compound 2 followed by compounds 1, 3 and 4 for both strains. It seemed that the mutagenic activity was lowered by the presence of hydrophobic group at C-17 whereas it was increased by the presence of the beta-acetyl group at C-6 in the steroid nucleus.