Effects of cyclosporin A on chromosomes and some serum enzymes in rats
Turkish Journal of Medical Sciences, vol.24, no.3, pp.181-184, 1995 (Scopus)
- Publication Type: Article / Article
- Volume: 24 Issue: 3
- Publication Date: 1995
- Journal Name: Turkish Journal of Medical Sciences
- Journal Indexes: Scopus
- Page Numbers: pp.181-184
- Keywords: chromosomes, cyclosporin A, serum enzymes
- Eskisehir Osmangazi University Affiliated: Yes
Abstract
The effects of different doses of cyclosporin A (2.5, 10, 25, 50 mg/kg/day) on chromosomes and serum enzymes in rats were investigated. Cyclosporin A (all doses) had no numerical effect on chromosomes. There was a dose-dependent increase of chromatid-type breakage, serum SGOT, SGPT, ALP and ASP levels according to the control. These increases were especially noted in the 50 mg/kg/day group.