The effect of nitric oxide on bacterial translocation due to obstructive jaundice

Ates E., Erkasap S., Cevadi M., Dundar E., Genc E., Yilmaz S., ...More

Eurosurgery 2000 Meeting, İstanbul, Turkey, 21 - 24 June 2000, pp.27-35, (Full Text) identifier

  • Publication Type: Conference Paper / Full Text
  • City: İstanbul
  • Country: Turkey
  • Page Numbers: pp.27-35
  • Keywords: obstructive jaundice bacterial translocation L arginin L-NAME, ENDOTOXIN, SHOCK
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

In order to evaluate the effect of the L-NAME which is an inhibitor of nitric oxide syntheses, on bacterial translocation and endotoxemia, 60 rats were subjected to complete ligation of common bile duct resulting in obstructive jaundice. All animals were divided into 3 groups namely control, Larginine and L-NAME. Additionally all groups were divided into a and b subgroups and followed up for 7 and 14 days respectively. At the end of the this follow up period animals were sacrificed in sterile condition and serum biochemical assay, microbiological examination of blood, peritoneum, cecal content and mesenteric lymph nodes and histopathological examination of liver and terminal ileum were carried out.