A single dose of aminophylline administration during therapeutic hypothermia; does it make a difference in glomerular filtration rate?

Surmeli Onay Ö., Gunes D., Aydemir Ö., Tekin N.

European journal of pediatrics, cilt.180, sa.11, ss.3367-3377, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 180 Sayı: 11
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s00431-021-04128-6
  • Dergi Adı: European journal of pediatrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.3367-3377
  • Anahtar Kelimeler: Acute kidney injury, Perinatal asphyxia, Aminophylline, Glomerular filtration rate, Urine output, Newborn, ACUTE KIDNEY INJURY, ACUTE-RENAL-FAILURE, PROPHYLACTIC THEOPHYLLINE, PERINATAL ASPHYXIA, TERM, DYSFUNCTION, NEWBORNS, ENCEPHALOPATHY, PREVENTION, CHILDREN
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

Aminophylline has been demonstrated to be effective in improving renal functions of the infants suffering from acute kidney injury (AKI) due to perinatal asphyxia. We aimed to evaluate the effect of a single-dose aminophylline on estimated glomerular filtration rate (eGFR), mine output (UO), and incidence and severity of AKI according to the pediatric-modified RIFLE and neonatal RIFLE criteria in newborns with perinatal asphyxia under therapeutic hypothermia. This was a single-center, retrospective cohort study including newborns (gestational age >= 36 weeks) who underwent therapeutic hypothermia due to hypoxic ischemic encephalopathy between 2016 and 2019. Demographic and clinical data were obtained from electronic medical records and patient files. Two patient groups were established: aminophylline group and control group which were only under therapeutic hypothermia. Twenty-one newborns were in the aminophylline group and 13 newborns were in the control group. Our study revealed that on the third day of life (DOL), eGFR was significantly higher in the control group (p=0.025), but UO was significantly higher in the aminophylline group (p=0.021). In the aminophylline group, eGFR on the first DOL was higher than the value on the second DOL (p=0.017) while UO was higher on the second and third DOL compared to the first DOL (1-2 DOL p=0.006, and 1-3 DOL p=0.004). However, in the control group, there was no statistically significant difference in UO over the four DOL. Both groups were similar in the presence, severity, and outcome of AKI.