Urological manifestations of the Wolfram syndrome: Observations in 14 patients

Tekgul S., Oge O., Simsek E., Yordam N., Kendi S.

JOURNAL OF UROLOGY, vol.161, no.2, pp.616-617, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 161 Issue: 2
  • Publication Date: 1999
  • Doi Number: 10.1016/s0022-5347(01)61982-7
  • Journal Name: JOURNAL OF UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.616-617
  • Keywords: Wolfram syndrome, diabetes mellitus, optic atrophy, deafness, bladder dysfunction, DIDMOAD SYNDROME
  • Eskisehir Osmangazi University Affiliated: No


Purpose: Since the initial description of the Wolfram syndrome, various anomalies have been associated with this rare entity. Urinary tract dilatation and bladder dysfunction, usually in the form of a large, atonic bladder, are coexisting features of this syndrome that are commonly believed to be secondary to high urine output in diabetes insipidus, The presentation and nature of the urological manifestations of this syndrome remain controversial due to the lack of large series in the literature. We evaluated the urological manifestations of this rare syndrome. To our knowledge we report the largest series of patients (14) with the Wolfram syndrome who underwent a complete urological evaluation.