Synthesis, Characterization, Antimicrobial Activity Study of a Novel Salt of Dipicolinic Acid with 2-Amino-5-Methylpyridine and Their Metal Complexes
Pharmaceutical Chemistry Journal, vol.58, no.12, pp.1821-1826, 2025 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 58 Issue: 12
- Publication Date: 2025
- Doi Number: 10.1007/s11094-025-03342-y
- Journal Name: Pharmaceutical Chemistry Journal
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, Chemical Abstracts Core
- Page Numbers: pp.1821-1826
- Keywords: 2,6-pyridinedicarboxylic acid, 2-amino-5-methylpyridine, antifungal and antibacterial activity, metal complex, proton transfer salt
- Eskisehir Osmangazi University Affiliated: Yes
Abstract
A new salt (1), obtained from pyridine-2,6-dicarboxylic acid (H2dpc) with and 2-amino-5-methylpyridine (2a5mp) and Fe(II) (2), Fe(III) (3), Co(II) (4), Ni(II) (5), Cu(II) (6) complexes and Co(II) complex (7) of H2 dpc were prepared and elucidated via 1H and 13C NMR for 1, UV, FT-IR, molar conductivity, magnetic measurement and AAS for 1-7 and x-ray crystallography for 7. Furthermore, the antifungal and antibacterial properties of all the compounds were also tested against C. krusei, C. albicans, C. parapisilosis, E. faecalis, E. coli and S. aureus. The outcomes were contrasted with those obtained with Vancomycin, Fluconazole, Cefepime and Levofloxacin (standard agents).