Perioperative alendronate, risedronate, calcitonin and indomethacin treatment alters femoral stem fixation and periprosthetic bone mineral density in ovariectomized rats

Cankaya D., Tabak Y., ÖZTÜRK A. M., Gunay M. C.

JOURNAL OF ORTHOPAEDIC SCIENCE, vol.20, no.4, pp.728-733, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.1007/s00776-015-0717-5
  • Journal Name: JOURNAL OF ORTHOPAEDIC SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.728-733
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Many factors affect implant stability and periprosthetic bone mineral density (BMD) following total joint arthroplasty. We asked whether perioperative alendronate, risedronate, calcitonin and indomethacine administration altered (1) femoral stem shear strength and periprosthetic bone mineral density BMD in ovariectomized rats and (2) whether there were differences in the effect of these drugs.