Protective effect of leptin against ischemia-reperfusion injury in the rat small intestine

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Hacioglu A., Algin C., Pasaoglu O., Pasaoglu E., Kanbak G.

BMC GASTROENTEROLOGY, vol.5, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5
  • Publication Date: 2005
  • Doi Number: 10.1186/1471-230x-5-37
  • Journal Name: BMC GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Eskisehir Osmangazi University Affiliated: Yes

Abstract

Background: The small intestine is extremely sensitive to ischemia-reperfusion (I/R) injury and a range of microcirculatory disturbances which contribute to tissue damage. Previous studies have shown that leptin plays an important physiological role in the microvasculature. The aim of this study was to evaluate the protective effects of leptin in I/R - induced mucosal injury in the small intestine.