Synthesis and X-ray crystal structure of the calcium channel antagonist: dimethyl 1,4-dihydro-2,6-dimethyl-4-[4'-(4H-4-oxo-1-benzopyran-2-yl)phenyl]-3,5-pyridine dicarboxylate

Tuncbilek M., Ozbey S., Kendi E., Yildirim E., Erol K., Ertan R.

Farmaco, cilt.54, sa.10, ss.660-665, 1999 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 10
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1016/s0014-827x(99)00076-2
  • Dergi Adı: Farmaco
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.660-665
  • Eskişehir Osmangazi Üniversitesi Adresli: Evet

Özet

The synthesis of the title compound via the Hantzsch method from 4'-flavone carboxaldehyde is described, and its molecular structure was determined by X-ray crystallography. The 1,4-dihydropyridine (1,4-DHP) ring adopts a boat conformation. The phenyl ring of the flavone is not exactly perpendicular to the DHP ring. Calcium antagonistic activity of this compound was evaluated in vitro by using BaCl2-stimulated rat ileum. Copyright (C) 1999 Elsevier Science S.A.