Modifiable chemically crosslinked poli(kappa-carrageenan) particles

Sagbas S., Butun S., ŞAHİNER N.

CARBOHYDRATE POLYMERS, cilt.87, sa.4, ss.2718-2724, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 87 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.carbpol.2011.11.064
  • Dergi Adı: CARBOHYDRATE POLYMERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2718-2724
  • Anahtar Kelimeler: kappa-Carrageenan microgels, Magnetic particles, Modifiable carrageenan particles, Drug delivery system, HYDROGEL PARTICLES, DELIVERY, NANOPARTICLES, CARRAGEENAN, CHITOSAN, QUATERNIZATION, KAPPA
  • Eskişehir Osmangazi Üniversitesi Adresli: Hayır

Özet

Micron size kappa-carrageenan hydrogel particles, p(CRN) from linear kappa-carrageenan, were prepared via microemulsion polymerization using divinyl sulfone (DVS) as chemical crosslinker in a sodium bis(2-ethylhexyl) sulfosuccinate (AOT) reverse miceller system. Magnetic field responsive (m-p(CRN)) composite particles were also synthesized by encapsulating magnetic ferrite (Fe3O4) nanoparticles together with linear kappa-carrageenan within the AOT reverse micelle before the crosslinking reaction. The synthesized bare p(CRN) particles were further modified to produce positive charges on the particles (q-p(CRN)) by a quaternization reaction with an 3-chloro-2-hydroxypropyl trimethyl ammonium chloride aqueous solution. Scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential measurements and FT-IR analysis confirmed that particle sizes and charges were altered by chemical modification. Furthermore, a model drug, phenylephrine HCI was used for in vitro drug delivery studies to compare the effectiveness of modification of p(CRN) microgels by comparing bare p(CRN), m-p(CRN) and q-p(CRN) particles drug release capabilities in phosphate buffer solution (PBS) at pH 7.4. (C) 2011 Elsevier Ltd. All rights reserved.